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Diagnosing MS


A careful process of physical findings, diagnostic test results, symptoms, and history makes the diagnosis of MS. There are certain criteria that physicians utilize when diagnosing Multiple Sclerosis:

  • Two separate and identifiable exacerbations at least one month apart. An exacerbation is a worsening of symptoms for at least a 48-hour period.

  • More than one area of damage to the Central Nervous System. This damage is as a result of demyelination.

    Diagnostic Tests


  • MRI (magnetic resonance imaging) is the preferred method of imaging the brain to determine the presence of lesions and/or scarring. An MRI better detects lesions/scarring than a CT scan.

    An MRI is a non-invasive diagnostic technique that utilizes split magnets and rapid real-time imaging so that the structure of the central nervous system is revealed. The patient lies in an enclosed tube, and the duration of the test lasts from 15 to 30 minutes. It is also important to note that the test is moderately noisy.

  • A Lumbar Puncture tests the cerebrospinal fluid for the presence of oligoclonal bands (elevated protein levels) within the spinal column. The presence oligoclonal bands indicate an immune response within the Central Nervous System.

    During this test, the physician inserts a long needle into the base of the spine to obtain spinal fluid. This test does involve some discomfort, and sometimes patients have headaches for a few days afterwards.

  • An Evoked Potential Test is an electrical study that determines if there is a slowing of messages in various parts of the brain. Normally, the Evoked Potential Test includes a hearing and vision portion.

    During this test, wires are attached to the scalp, neck and limbs.

    This test records how quickly and completely the nerve signals provoked by the stimulation reach the brain. In MS, signal transmission slows down somewhat.

    The use of diagnostic testing is not "full proof", and there are times when physicians will not base their determination solely on these tests. It is important to mention that there are other illnesses/conditions that mimic MS and need to be ruled out prior to a doctor confirming his diagnosis.

    During the diagnosis process, physicians will schedule a battery of blood work to rule out other illnesses. There is no blood test that can determine MS, however, it is necessary to have this testing done in order to rule out other conditions.

    Finally, neurological examination and history evaluations will be conducted. During this process, an extensive review of your medical history and symptoms will be discussed. The physician will perform a variety of testing that includes movement, coordination, vision, balance, and other functions of the five senses.

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